There are other ways that vasodilation can be helped. For example, NO, itself can also help induce a lower blood pressure by inhibiting endothelin-1, a vasoconstrictor. In this mechanism, arginine is useful because more NO production means more inhibition of vasoconstrictors. Further, NO also has an influence as an antiatherogenic, antiproliferative and antithrombotic (Wu & Meininger, 2000). By reducing hypertension, the goal is to reduce the risk of cardiovascular disease. According to various clinical trials, it is proven that low blood pressure will lower CV diseases such as myocardial infarction by 20-25%, stroke by 35-40% and heart failure by 50% (Antonakoudis et al., 2007).
So far, the mechanisms surrounding L-arginine and the importance of L-arginine supplementation can be seen through these evidences. Therefore, managing the risk of hypertension should not be left to be fulfilled solely by the amount of arginine that is produced by the body. Supplementation is important, especially when regulating hypertension via orally or intravenously. An important way to supplement is following the DASH diet. The DASH diet provides arginine and other nutrients that help lower blood pressure. Combining the DASH diet to ones’ regular diet can vastly improve their cardiovascular health and help regulate hypertension.
Arginine is an important amino acid in helping regulate hypertension, and ultimately, CVD. By increasing NO production, and generating cyclic (c)GMP to help vessels vasodilate, it reduces the risk of many diseases affected by hypertension. NO production is very crucial in this mechanism to reduce hypertension. NO that is produced via eNOS process, allows many benefits to cardiovascular health. It acts as a vasodilator, antiatherogenic, antiproliferative, antithrombotic and also promotes angiogenesis (Wu & Meininger, 2000). Arginine is very important to produce NO; therefore, it should be consumed by at risk or cardiovascular patients.
Arginine is a semi-essential amino acid; therefore, supplementation is important. If an individual possesses CVD, supplementation should be provided via orally or intravenously. Otherwise, combining diets such as the DASH diet to ones’ regular diet can be used as supplementation in everyday life. L-arginine containing foods such as soy, fish, beans, lentils, and nuts can be included in a regular diet. Managing hypertension is important because it can have a major effect on life-threatening cardiovascular diseases.
As for future research, there are some areas without evidence that could require more research. It was mentioned that that different amino acids such as cysteine, glutamate, leucine, taurine, tryptophan, and arginine reduce hypertension via different processes such as insulin resistance, advanced glycation, oxidative stress. However, the mechanisms of action behind these processes do not have enough research or evidence. Therefore, future research could direct its resources to find the reasoning or mechanisms behind these effects.
Also, several articles mentioned the importance of supplementation orally and intravenously. Understanding which method has a better effect on the discussed mechanism was not mentioned. It would be useful if more research is conducted to differentiate the two methods to figure out the effectiveness. Finally, the importance of NO to hypertension is very evident through these articles. Some articles stated that NO has additional processes for reducing and improving CVD such as angiogenesis, antiatherogenic properties. Research about how arginine is connected to these processes may be useful in understanding the full potential of arginine to hypertension.