Periodontal regeneration therapy among other dental stem cells. However,

ligament (PDL) tissue plays a
significant role in tooth
preservation by anchoring the connection between the cementum on tooth root and
the bony tooth socket, which provides support,
protection and provision of sensory input to the masticatory system. PDL tissue
can become compromised or irreversibly damaged by trauma and
infectious disease, such as periodontitis
and deep dental caries that lead to causes tooth loss. Tissue engineering is a
therapeutic approach in regenerative dentistry that aims to induce new functional
tissue regeneration by the synergistic combination of cells, scaffolds, and signaling
molecules in many cases. However, these therapies are limited by the severity
of periodontitis, Reconstructed PDL volume is incomplete. Consequently, recent
tissue engineering techniques based on stem cell biology have been proposed for
developing such a therapy. to reconstruct PDL tissue destroyed.

Stem cells in Periodontal
ligament tissue cells (PDLSCs), which are derived from neural crest cell and
involved in maintenance, proliferation,
self-renewal, differentiation, multipotentiality and surface markers expression of stem cells. It has been considered that PDLSCs
were the most suitable cells for periodontal tissue regeneration therapy among
other dental stem cells. However, there remain a number of limitations
affecting their therapeutic efficiency. As the significant proliferation and
differentiation capacities, recently described induced pluripotent stem (iPS) cells
that can be effectively generated from tissues which are easily accessed by
dentist provide a novel approach on cell-based therapies for periodontal

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PDL tissue, The extracellular matrix (ECM)
key roles in determining stem cell niche that
facilitate periodontal regeneration. It is composed of both collagenous and
non-collagenous protein with several molecule components
on stem cell behavior. However, rare study has explored small-molecule in periodontal
ECM to induce iPS cell. Therefore, the topic that I would like to do research
in Japan is “”Influence of small-molecule
compounds on periodontal tissue development of induced pluripotent stem (iPS)